People, we don't need any of these things to be important. If we are talking about pain, we are talking about something that occurs in the brain, not in the spine, or the muscles, or the joints. The nervous system and the complexity of perception and processing of pain is more than adequate as an explanatory model to drive our treatments. Approaches that target the brain or nervous tissue first would seem most concordant with the existing science. Traditional types of manual therapy are perfectly aligned with modern science if they rely on patient response to drive treatment decisions rather than stories about joint positioning, alignment, or "restrictions" of some kind.
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